Genetics of systemic sclerosis
نویسندگان
چکیده
منابع مشابه
Systemic sclerosis: genetics and epigenetics.
Systemic sclerosis (SSc) is an autoimmune disease characterized by immune abnormalities, vascular obliteration, excessive extracellular matrix deposition, and fibrosis of the skin and/or internal organs. To date, the exact etiology of this complicated disease remains unknown. Over the past few years, however, the role of genetic susceptibility and epigenetic modifications caused by environmenta...
متن کاملGenetics of systemic sclerosis: recent advances
PURPOSE OF REVIEW Large-scale and follow-up genetic association studies in systemic sclerosis (SSc) have implicated over 40 regions in disease risk, 15 of which with robust associations. Nevertheless, the causal variants and the functional mechanisms underlying the genetic associations remain elusive, and the reasons for the higher disease burden in African Americans unknown. Incorporating tool...
متن کاملThe genetics of scleroderma (systemic sclerosis).
PURPOSE OF REVIEW To determine the advances made in the genetics of scleroderma in candidate gene association studies. RECENT FINDINGS Over the past 18 months, a number of candidate gene studies using large case-control series in scleroderma have been reported. The studies have identified multiple genes involved in immune regulation including BANK1, C8orf13-BLK, IL-23R, IRF5, STAT4, TBX21, an...
متن کاملGenetics of Systemic Sclerosis: An Update
Systemic sclerosis (SSc) is an autoimmune disease characterized by vasculopathy, immune cell activation, and fibrosis of the skin and internal organs. Over the past few years, a role for genetics in the susceptibility for SSc has been established. This review aims to provide an update on the progress made in the past year or so within the field of SSc genetics research. This year has been of pa...
متن کاملGenetics and genomic studies in scleroderma (systemic sclerosis).
It currently is believed that scleroderma is a complex polygenic disease that occurs in genetically predisposed individuals who have encountered specific environment exposures and/or other stochastic factors. The nature of these genetic determinants and how they interact with environmental factors are areas of active investigation. This article discusses the evidence that supports a strong gene...
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ژورنال
عنوان ژورنال: Current Opinion in Rheumatology
سال: 2015
ISSN: 1040-8711
DOI: 10.1097/bor.0000000000000214